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Sleep Board Review Test 16. Which of the following HLAs are associated with patients with narcolepsy with
cataplexy? a. HLA DQB1*0601 b. HLA DQB1*0602 c. HLA DQB1*0603 d. HLA DQB1*0604 e. HLA DQB1*0605 Answer: b HLA DQB1*0602 HLA DQB1*0602 is found in
patients with narcolepsy with cataplexy in 85-100% of white patients, 90-95%
of African American patients, and 100% of Japanese patients. This HLA allele is found in a
significant number of control subjects without narcolepsy (22% white, 34%
African American, 12% Japenese). Therefore it can support a diagnosis
of narcolepsy but is not diagnostic of narcolepsy. Reference: Kryger et al, Principles and Practice of Sleep Medicine,
4th edition, 2005; page 766. |
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