Sleep Board Review Test 1

29. Which of the following medications used for the treatment of excessive daytime somnolence in patients with narcolepsy does not have any anti-cataplectic activity?

a. methylphenidate

b. modafinil

c. sodium oxybate

d. methamphetamine

e. dextroamphetamine

Answer: b modafinil

Modafinil is a wake promoting agent that does not have any anticataplectic activity. Methylphenidate, methamphetamine and dextroamphetamine are all amphetamines which have stimulant properties and anticataplectic activity. Sodium oxybate is approved for the treatment of EDS and cataplexy in patients with narcolepsy.

Reference:

Scammell, TE, Ann Neuro 2003;53:154-166.

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