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Sleep Board Review Test 11. Modafinil has been used to treat
patients with Shift Work Sleep Disorder.
In a major study modafinil was shown to have
all of the following outcomes EXCEPT: a. improved mean sleep latency b. increase in daytime sleep onset
latency c. more patients demonstrated an
improvement in symptoms d. a reduction in frequency and duration
of lapses on the psychomotor vigilance test e. reduction in motor vehicle accidents
or near misses while commuting home Answer: b. increase in daytime sleep onset
latency The
U.S. Modafinil in Shift Work Sleep Disorder Study Group reported on the use
of modafinil in patients with shift work sleep
disorder compared to placebo. The
patients treated with modafinil had a small
increase in sleep latency at work
(1.7 vs. 0.3 min; P=0.002), more patients had
improvement in their clinical symptoms (74% vs. 36%; P<0.001),
a reduction in the frequency and duration of lapses of attention
during nighttime testing of their performance on the Psychomotor
Vigilance Test (change from baseline, a reduction in lapse
frequency of 2.6 vs. an increase of 3.8, respectively;
P<0.001), and fewer patients reported having had accidents or near
accidents while commuting home (29% vs. 54%; P<0.001). Modafinil did not adversely affect
daytime sleep. Reference: |
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