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Techniques for identify the function of different areas of the brain:

• Transection

– Section the brain in half and look for results

• Lesioning

– Damage the neurons and axons passing by

– Selectively damage the neurons and leave the axons intact

– Look for loss of function

• Record electrical activity of regions with implanted electrodes

• Electrical stimulation of regions

– Look for gain of function

Click the links below for more information:

Neuroanatomy of Wakefulness

Neurochemicals of Wakefulness

Neuroanatomy of Sleep

Neurochemicals of Sleep

References:

Kryger, Principles and Practice of Sleep Medicine, Elsevier 2005

Sleep Neurobiology for the Clinician. Espana and Scammell. Sleep 2004;27:811. (excellent review)

Hypocretins (orexins) and sleep-wake disorders. Lancet Neuro 2005; 4:673.

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